Has an AFL game ever ended 100-41?
Exactly once. On August 30, 1919, Richmond beat St Kilda 100-41, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 100-41 in league history.
That makes 100-41 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 101-41 has happened 1 times and 100-42 has happened 1 times.