Has an AFL game ever ended 100-43?
Exactly once. On June 18, 2016, Geelong beat Footscray 100-43, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 100-43 in league history.
That makes 100-43 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 101-43 has happened never and 100-44 has happened 2 times.