Has an AFL game ever ended 100-49?
Exactly once. On August 28, 1948, Footscray beat Sydney 100-49, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 100-49 in league history.
That makes 100-49 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 101-49 has happened 8 times and 100-50 has happened never.