Has an AFL game ever ended 108-42?
Exactly once. On September 6, 2020, Geelong beat Essendon 108-42, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 108-42 in league history.
That makes 108-42 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 109-42 has happened never and 108-43 has happened 1 times.