Has an AFL game ever ended 109-49?
Exactly once. On July 19, 1930, Richmond beat Hawthorn 109-49, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 109-49 in league history.
That makes 109-49 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 110-49 has happened 1 times and 109-50 has happened 4 times.