Has an AFL game ever ended 110-49?
Exactly once. On May 8, 1982, Carlton beat Geelong 110-49, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 110-49 in league history.
That makes 110-49 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 111-49 has happened 5 times and 110-50 has happened never.