Has an AFL game ever ended 110-78?
Yes. AFL has seen a final score of 110-78 5 times. It first happened on May 20, 1950, when Essendon beat Richmond, and most recently on June 12, 2016, when St Kilda beat Carlton.
That makes 110-78 the 589th most common final score out of 6,607 that have ever occurred in AFL. One point away, 111-78 has happened 3 times and 110-79 has happened 4 times. At one point the score disappeared for 26 years, between 1950 and 1976.