Has an AFL game ever ended 110-81?
Yes. AFL has seen a final score of 110-81 4 times. It first happened on June 23, 1934, when Richmond beat Hawthorn, and most recently on August 6, 2016, when Melbourne beat Hawthorn.
That makes 110-81 the 947th most common final score out of 6,607 that have ever occurred in AFL. One point away, 111-81 has happened 4 times and 110-82 has happened 4 times. At one point the score disappeared for 41 years, between 1975 and 2016.