Has an AFL game ever ended 115-43?
Exactly once. On July 12, 2015, Hawthorn beat Fremantle 115-43, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 115-43 in league history.
That makes 115-43 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 116-43 has happened never and 115-44 has happened 1 times.