Has an AFL game ever ended 120-48?
Yes. AFL has seen a final score of 120-48 2 times. It first happened on May 16, 1992, when Hawthorn beat Melbourne, and most recently on April 4, 2010, when Footscray beat Richmond.
That makes 120-48 the 2421st most common final score out of 6,607 that have ever occurred in AFL. One point away, 121-48 has happened 2 times and 120-49 has happened 1 times.