Has an AFL game ever ended 121-100?
Yes. AFL has seen a final score of 121-100 4 times. It first happened on May 24, 1980, when Sydney beat Fitzroy, and most recently on April 25, 2009, when Fremantle beat Sydney.
That makes 121-100 the 1005th most common final score out of 6,649 that have ever occurred in AFL. One point away, 122-100 has happened 1 times and 121-101 has happened 3 times. Nearly all of its occurrences fall between 1980 and 2009.