Has an AFL game ever ended 121-35?
Exactly once. On May 4, 1997, St Kilda beat Melbourne 121-35, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 121-35 in league history.
That makes 121-35 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 122-35 has happened never and 121-36 has happened 1 times.