Has an AFL game ever ended 121-45?
Exactly once. On May 26, 1928, Footscray beat Hawthorn 121-45, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 121-45 in league history.
That makes 121-45 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 122-45 has happened 3 times and 121-46 has happened never.