Has an AFL game ever ended 121-78?
Yes. AFL has seen a final score of 121-78 2 times. It first happened on September 11, 1926, when Melbourne beat Hawthorn, and most recently on April 15, 1995, when Fremantle beat Fitzroy.
That makes 121-78 the 2421st most common final score out of 6,607 that have ever occurred in AFL. One point away, 122-78 has happened 7 times and 121-79 has happened 1 times. At one point the score disappeared for 69 years, between 1926 and 1995.