Has an AFL game ever ended 121-85?
Exactly once. On August 15, 2015, Hawthorn beat Geelong 121-85, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 121-85 in league history.
That makes 121-85 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 122-85 has happened 1 times and 121-86 has happened never.