Has an AFL game ever ended 122-100?
Exactly once. On March 29, 1980, Melbourne beat St Kilda 122-100, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 122-100 in league history.
That makes 122-100 the 3883rd most common final score out of 6,649 that have ever occurred in AFL. One point away, 123-100 has happened never and 122-101 has happened 2 times.