Has an AFL game ever ended 122-110?
Exactly once. On August 31, 1935, St Kilda beat Melbourne 122-110, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 122-110 in league history.
That makes 122-110 the 3883rd most common final score out of 6,649 that have ever occurred in AFL. One point away, 123-110 has happened 3 times and 122-111 has happened 1 times.