Has an AFL game ever ended 151-59?
Exactly once. On July 23, 1966, Melbourne beat Hawthorn 151-59, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 151-59 in league history.
That makes 151-59 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 152-59 has happened 2 times and 151-60 has happened never.