Has an AFL game ever ended 159-41?
Exactly once. On August 15, 1999, Sydney beat Adelaide 159-41, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 159-41 in league history.
That makes 159-41 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 160-41 has happened never and 159-42 has happened never.