Has an AFL game ever ended 159-50?
Exactly once. On May 20, 2018, Melbourne beat Carlton 159-50, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 159-50 in league history.
That makes 159-50 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 160-50 has happened never and 159-51 has happened never.