Has an AFL game ever ended 161-48?
Exactly once. On August 27, 1994, Carlton beat Richmond 161-48, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 161-48 in league history.
That makes 161-48 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 162-48 has happened never and 161-49 has happened never.