Has an AFL game ever ended 165-49?
Exactly once. On May 31, 1986, Carlton beat Melbourne 165-49, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 165-49 in league history.
That makes 165-49 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 166-49 has happened never and 165-50 has happened never.