Has an AFL game ever ended 165-53?
Exactly once. On August 24, 1946, Footscray beat Hawthorn 165-53, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 165-53 in league history.
That makes 165-53 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 166-53 has happened never and 165-54 has happened never.