Has an AFL game ever ended 165-61?
Exactly once. On August 25, 2018, Adelaide beat Carlton 165-61, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 165-61 in league history.
That makes 165-61 the 3883rd most common final score out of 6,649 that have ever occurred in AFL. One point away, 166-61 has happened never and 165-62 has happened never.