Has an AFL game ever ended 180-49?
Exactly once. On March 30, 1991, Melbourne beat Fitzroy 180-49, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 180-49 in league history.
That makes 180-49 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 181-49 has happened 1 times and 180-50 has happened never.