Has an AFL game ever ended 181-49?
Exactly once. On April 30, 1983, Essendon beat Footscray 181-49, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 181-49 in league history.
That makes 181-49 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 182-49 has happened never and 181-50 has happened never.