Has an AFL game ever ended 45-22?
Exactly once. On June 29, 1918, Richmond beat Essendon 45-22, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 45-22 in league history.
That makes 45-22 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 46-22 has happened never and 45-23 has happened never.