Has an AFL game ever ended 48-16?
Exactly once. On July 27, 2020, Geelong beat Fremantle 48-16, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 48-16 in league history.
That makes 48-16 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 49-16 has happened 1 times and 48-17 has happened never.