Has an AFL game ever ended 48-25?
Exactly once. On May 17, 1902, Essendon beat Melbourne 48-25, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 48-25 in league history.
That makes 48-25 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 49-25 has happened 1 times and 48-26 has happened never.