Has an AFL game ever ended 49-16?
Exactly once. On May 8, 1897, Fitzroy beat Carlton 49-16, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 49-16 in league history.
That makes 49-16 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 50-16 has happened never and 49-17 has happened never.