Has an AFL game ever ended 54-16?
Exactly once. On August 6, 1910, Richmond beat St Kilda 54-16, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 54-16 in league history.
That makes 54-16 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 55-16 has happened never and 54-17 has happened never.