Has an AFL game ever ended 54-22?
Yes. AFL has seen a final score of 54-22 4 times. It first happened on August 7, 1897, when Collingwood beat Carlton, and most recently on May 11, 1912, when Sydney beat Melbourne.
That makes 54-22 the 947th most common final score out of 6,607 that have ever occurred in AFL. One point away, 55-22 has happened 3 times and 54-23 has happened 1 times. Nearly all of its occurrences fall between 1890 and 1919.