Has an AFL game ever ended 65-10?
Exactly once. On August 20, 1898, Fitzroy beat Sydney 65-10, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 65-10 in league history.
That makes 65-10 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 66-10 has happened never and 65-11 has happened never.