Has an AFL game ever ended 65-22?
Exactly once. On June 3, 1901, Geelong beat Sydney 65-22, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 65-22 in league history.
That makes 65-22 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 66-22 has happened 1 times and 65-23 has happened never.