Has an AFL game ever ended 65-41?
Exactly once. On July 15, 1905, Essendon beat Melbourne 65-41, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 65-41 in league history.
That makes 65-41 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 66-41 has happened 2 times and 65-42 has happened 2 times.