Has an AFL game ever ended 65-43?
Exactly once. On June 28, 2013, Sydney beat Carlton 65-43, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 65-43 in league history.
That makes 65-43 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 66-43 has happened 3 times and 65-44 has happened 4 times.