Has an AFL game ever ended 68-22?
Exactly once. On July 4, 1914, Geelong beat Melbourne 68-22, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 68-22 in league history.
That makes 68-22 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 69-22 has happened never and 68-23 has happened 1 times.