Has an AFL game ever ended 72-27?
Exactly once. On July 16, 1921, Geelong beat Essendon 72-27, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 72-27 in league history.
That makes 72-27 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 73-27 has happened never and 72-28 has happened never.