Has an AFL game ever ended 75-45?
Yes. AFL has seen a final score of 75-45 2 times. It first happened on May 14, 1910, when Carlton beat Geelong, and most recently on July 4, 1942, when Sydney beat Footscray.
That makes 75-45 the 2421st most common final score out of 6,607 that have ever occurred in AFL. One point away, 76-45 has happened never and 75-46 has happened 4 times. At one point the score disappeared for 32 years, between 1910 and 1942.