Has an AFL game ever ended 78-25?
Exactly once. On August 10, 1907, Carlton beat Essendon 78-25, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 78-25 in league history.
That makes 78-25 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 79-25 has happened never and 78-26 has happened 1 times.