Has an AFL game ever ended 78-43?
Exactly once. On April 24, 1971, Melbourne beat Essendon 78-43, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 78-43 in league history.
That makes 78-43 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 79-43 has happened never and 78-44 has happened 1 times.