Has an AFL game ever ended 80-24?
Exactly once. On May 27, 1995, St Kilda beat Carlton 80-24, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 80-24 in league history.
That makes 80-24 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 81-24 has happened never and 80-25 has happened 1 times.