Has an AFL game ever ended 80-28?
Exactly once. On April 21, 2013, Adelaide beat Footscray 80-28, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 80-28 in league history.
That makes 80-28 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 81-28 has happened never and 80-29 has happened never.