Has an AFL game ever ended 80-45?
Yes. AFL has seen a final score of 80-45 3 times. It first happened on July 17, 1909, when Essendon beat Geelong, and most recently on July 12, 1930, when Sydney beat North Melbourne.
That makes 80-45 the 1534th most common final score out of 6,607 that have ever occurred in AFL. One point away, 81-45 has happened never and 80-46 has happened 2 times.