Has an AFL game ever ended 81-38?
Exactly once. On May 21, 1921, Essendon beat Sydney 81-38, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 81-38 in league history.
That makes 81-38 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 82-38 has happened 2 times and 81-39 has happened never.