Has an AFL game ever ended 81-48?
Yes. AFL has seen a final score of 81-48 2 times. It first happened on June 13, 1908, when St Kilda beat Fitzroy, and most recently on July 9, 1949, when Carlton beat Sydney.
That makes 81-48 the 2495th most common final score out of 6,649 that have ever occurred in AFL. One point away, 82-48 has happened 7 times and 81-49 has happened 4 times. At one point the score disappeared for 41 years, between 1908 and 1949.