Has an AFL game ever ended 88-42?
Exactly once. On June 8, 2017, Sydney beat Footscray 88-42, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 88-42 in league history.
That makes 88-42 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 89-42 has happened 2 times and 88-43 has happened 2 times.