Has an AFL game ever ended 99-22?
Exactly once. On May 24, 1919, Carlton beat Geelong 99-22, and no AFL game before or since has ended that way. When it happened it was a scorigami, the first 99-22 in league history.
That makes 99-22 the 3836th most common final score out of 6,607 that have ever occurred in AFL. One point away, 100-22 has happened never and 99-23 has happened 1 times.