Has an MLB game ever ended 18-2?
Yes. MLB has seen a final score of 18-2 47 times. It first happened on September 5, 1879, when Cincinnati Reds beat Syracuse Stars, and most recently on September 7, 2025, when Seattle Mariners beat Atlanta Braves.
That makes 18-2 the 144th most common final score out of 330 that have ever occurred in MLB. One point away, 19-2 has happened 34 times and 18-3 has happened 51 times. At one point the score disappeared for 30 years, between 1905 and 1935.