Has an MLB game ever ended 19-5?
Yes. MLB has seen a final score of 19-5 25 times. It first happened on July 8, 1880, when Boston Red Caps beat Cincinnati Reds, and most recently on May 23, 2025, when Boston Red Sox beat Baltimore Orioles.
That makes 19-5 the 166th most common final score out of 330 that have ever occurred in MLB. One point away, 20-5 has happened 22 times and 19-6 has happened 32 times. At one point the score disappeared for 30 years, between 1948 and 1978.